The HT-RDS center is equipped with cutting-edge technology with the goal of accelerating every step of synthetic research, from reaction planning to execution to analysis. This enables the generation of larger data outputs in a shorter period of time. In combination with modern data science tools, such as machine learning, this facilitates more guided and rapid optimization of chemical processes towards desired outcomes, allowing for faster development of research programs.
Reaction Set-Up
Vigor’s Stainless Steel Seven-Glove Box Integrated with Vigor’s Solvent-Purification System
for ligand library preparation and storage, and for setting up reaction screening
Thermo Fischer Scientific’s SPD120 evaporator
for concentration of reaction plates and ligand library preparation
Reaction Execution
Analytical Sales and Service’s 48-Position Synthesis Reaction Blocks, Gen II;
Analytical Sales and Service’s 96-Position Synthesis Reaction Blocks, Gen II;
Analytical Sales and Service’s 48-Position Temperature Controlled Reactor
for conducting high numbers of parallel experiments
VP Scientific’s VP 741D Heating Blocks
for screening reactions requiring elevated temperatures
Lumidox®II 48-Position LED Arrays
for performing photochemical experiments
Thermo Fischer Scientific’s AC200-A45 Refrigerated Bath Circulator
for temperature control of photochemical experiments
Analysis
Shimadzu’s Nexera UC with Single Quadrupole LCMS-2050 (SFC-MS)
for determination of stereoselectivity in enantioselective transformations
Agilent’s Intuvo 9000 GC with 5977B Single Quadrupole MS and Flame Ionization Detector
for reaction discovery and optimization of chemical yield
Agilent’s 1290 Infinity II Series HPLC with Single Quadrupole MS
for reaction discovery and optimization of chemical yield
Advion’s Expression-L Compact Mass Spectrometer with Plate Express
for analysis of mixtures using direct or solution based injections, as well as
for analysis of TLCs
Purification
Agilent’s 1260 Infinity II Series Semi-Preparative HPLC with Single Quadrupole MS
for purification of samples towards biological studies or structure determination
Other Instrumentation
CIQTEK’s Benchtop X-band Electron Paramagnetic Resonance Spectrometer EPR200M
for detection and characterization of persistent radical species