Center for High-Throughput Reaction Discovery & Synthesis

Publications

  • Highly Enantioselective Synthesis of Halogenated Cyclopropanes via Enzyme-Catalyzed Carbene Transfer

    Ronald D. Adukure, Muhammed Fastheem, Vince Lombardo, Ryan Daley, Matthew Robinson, Tay Rosenthal, Rudi Fasan*

    ChemCatChem 2025, 17, e00949

    ChemCatChem 2025, 17, e00949

  • Photobiocatalytic Enantioselective Benzylic C(sp3)–H Acylation Enabled by Thiamine-Dependent Enzymes via Intermolecular Hydrogen Atom Transfer

    Yen-Chu Lu, Ronald D. Adukure, Satyajit Roy, Derek L. Chien, Matthew J. McGill, Sarthi Polara, G. Andrés Cisneros, Karl A. Scheidt, Rudi Fasan*

    J. Am. Chem. Soc. 2025, 147, 17804-17816

    J. Am. Chem. Soc. 2025, 147, 17804-17816

  • Chemoenzymatic Skeletal Editing of Natural Product Scaffolds via P450-Controlled Site-Selective Ring Expansion at Aliphatic C─H Sites

    John M. Bennett, Andrew R. Bortz, Zheyuan Wang, Muhammed Fastheem, Rudi Fasan*

    Angew. Chem. Int. Ed. 2025, 64, e202512576

    Angew. Chem. Int. Ed. 2025, 64, e202512576

  • General Light-Induced Pd-Catalyzed Allylic C–H Alkylation of Internal Alkenes: Direct Access to Tertiary and Quaternary Carbon Centers

    Subham Pradhan#, Gaurav Prakash#, Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, 147, 43213–43222

    J. Am. Chem. Soc. 2025, ASAP

  • Transition-Metal-Free Site-Selective β– and γ-C–H Borylation of Aliphatic Amines

    Sumon Sarkar,# Nitish Kumar Deo,# Tong Zhang, and Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, 147, 40064–40070

    J. Am. Chem. Soc. 2025, 147, 40064–40070

  • Nickel-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Alkenes toward Skipped Enones

    Sidhant Wagulde#, Pramod Rai#, Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, 147, 34211–34217

    J. Am. Chem. Soc. 2025, 147, 34211–34217

  • Directed Halogen Atom Transfer (DIXAT): A Powerful Tool for Chemoselective Generation of Aryl Radicals toward Remote C(sp3)–H Functionalization of Aliphatic Amines.

    Sidhant Wagulde, Kevin P. Quirion, Turki M. Alturaifi, Peng Liu*, Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, 147, 29367–29376

    J. Am. Chem. Soc. 2025, 147, 29367–29376

  • Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds

    Nikita Kvasovs#, Valeria Iziumchenko#, Alistair J. Sterling, Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, 147, 8093–8100

    J. Am. Chem. Soc. 2025, ASAP

  • Enantioselective Total Syntheses of Vallesamidine and Schizozygane Alkaloids

    Gujjula V. Ramakrishna, Zurwa Latif, Filippo Romiti*

    J. Am. Chem. Soc. 2025, 147, 4613−4623

    J. Am. Chem. Soc. 2025, 147, 4613−4623

  • Highly Enantioselective Construction of Oxazolidinone Rings via Enzymatic C(sp3)–H Amination

    Jadab Majhi#, Satyajit Roy#, Anwita Chattopadhyay, Rudi Fasan*

    ACS Catal. 2024, 15, 809–816

    ACS Catal. 2024, 15, 809–816

  • Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles

    Roy Satyajit, Yining Wang, Xinyi Zhao, Thakshila Dayananda, Jian-Min Chu, Yong Zhang*, Rudi Fasan*

    J Am Chem Soc. 2024, 146, 19673-19679

    J Am Chem Soc. 2024, 146,19673-19679

Representative Work

  • Beyond Strain Release: Delocalization-Enabled Organic Reactivity

    Alistair J. Sterling,* Russell C. Smith, Edward A. Anderson,* Fernanda Duarte*

    J. Org. Chem. 2024, 89, 9979−9989

    J. Org. Chem. 2024, 89, 9979−9989

  • Stereoselective Construction of β-, γ- and δ-Lactam Rings Via Enzymatic C–H Amidation

    Satyajit Roy, David A. Vargas, Pengchen Ma, Arkajyoti Sengupta, Ledong Zhu, Kendall N. Houk*, Rudi Fasan*

    Nat. Catal. 2024, 7, 65-76

    Nature Catalysis 2024, 7, 65-76

  • Biocatalytic Strategy for the Construction of sp3-Rich Polycyclic Compounds from Directed Evolution and Computational Modelling

    David A. Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N. Houk*, Rudi Fasan*

    Nat. Chem. 2024, 16, 817-826

    Nature Chemistry 2024, 16, 817-826

  • Mechanistic Insights into the Origins of Selectivity in a Cu-Catalyzed C–H Amidation Reaction

    Alistair J. Sterling*, Nicodemo R. Ciccia, Yifan Guo, John F. Hartwig*, Martin Head-Gordon*

    J. Am. Chem. Soc. 2024, 146, 6168-6177

    J. Am. Chem. Soc. 2024, 146, 6168-6177

  • Catalytic Prenyl Conjugate Additions for Synthesis of Enantiomerically Enriched PPAPs

    Shawn Ng, Casey P. Howshall, Thanh-Nhat Ho, Khanh Bin Mai, Yuebiao Zhou, Can Qin, Kai Ze Tee, Peng Liu*, Filippo Romiti*, Amir H. Hoveyda*

    Science 2024, 386, 167-175

    Science 2024, 386, 167-175

  • One-Pot Formal Carboradiofluorination of Alkenes: A Toolkit for
    Positron Emission Tomography Imaging Probe Development

    Mónica Rivas,# Sashi Debnath,# Sachin Giri, Yusuf M. Noffel, Xiankai Sun,* Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2023, 145, 19265−19273

    J. Am. Chem. Soc. 2023, 145, 19265−19273

  • Streamlined Strategy for Scalable and Enantioselective Total
    Syntheses of the Eburnane Alkaloids

    Gujjula V. Ramakrishna,† Larisa P. Pop,† Zurwa Latif, Harish K. V. Suryadevara, Luca Santo, Filippo Romiti*

    J. Am. Chem. Soc. 2023, 145, 20062−20072

    J. Am. Chem. Soc. 2023, 145, 20062−20072

  • Asymmetric Intermolecular Allylic C–H Amination of Alkenes With Aliphatic Amines

    Kelvin Pak Shing Cheung, Jian Fang, Kallol Mukherjee, Andranik Mihranyan, Vladimir Gevorgyan*

    Science 2022, 378, 1207-1213

    Science 2022, 378,1207-1213