Center for High-Throughput Reaction Discovery & Synthesis

Publications

  • Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds

    Nikita Kvasovs#, Valeria Iziumchenko#, Alistair J. Sterling, Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2025, ASAP

    J. Am. Chem. Soc. 2025, ASAP

  • Enantioselective Total Syntheses of Vallesamidine and Schizozygane Alkaloids

    Gujjula V. Ramakrishna, Zurwa Latif, Filippo Romiti*

    J. Am. Chem. Soc. 2025, 147, 4613−4623

    J. Am. Chem. Soc. 2025, 147, 4613−4623

  • Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles

    Roy Satyajit, Yining Wang, Xinyi Zhao, Thakshila Dayananda, Jian-Min Chu, Yong Zhang*, Rudi Fasan*

    J Am Chem Soc. 2024, 146, 19673-19679

    J Am Chem Soc. 2024, 146,19673-19679

Representative Work

  • Beyond Strain Release: Delocalization-Enabled Organic Reactivity

    Alistair J. Sterling,* Russell C. Smith, Edward A. Anderson,* Fernanda Duarte*

    J. Org. Chem. 2024, 89, 9979−9989

    J. Org. Chem. 2024, 89, 9979−9989

  • Stereoselective Construction of β-, γ- and δ-Lactam Rings Via Enzymatic C–H Amidation

    Satyajit Roy, David A. Vargas, Pengchen Ma, Arkajyoti Sengupta, Ledong Zhu, Kendall N. Houk*, Rudi Fasan*

    Nat. Catal. 2024, 7, 65-76

    Nature Catalysis 2024, 7, 65-76

  • Biocatalytic Strategy for the Construction of sp3-Rich Polycyclic Compounds from Directed Evolution and Computational Modelling

    David A. Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N. Houk*, Rudi Fasan*

    Nat. Chem. 2024, 16, 817-826

    Nature Chemistry 2024, 16, 817-826

  • Mechanistic Insights into the Origins of Selectivity in a Cu-Catalyzed C–H Amidation Reaction

    Alistair J. Sterling*, Nicodemo R. Ciccia, Yifan Guo, John F. Hartwig*, Martin Head-Gordon*

    J. Am. Chem. Soc. 2024, 146, 6168-6177

    J. Am. Chem. Soc. 2024, 146, 6168-6177

  • Catalytic Prenyl Conjugate Additions for Synthesis of Enantiomerically Enriched PPAPs

    Shawn Ng, Casey P. Howshall, Thanh-Nhat Ho, Khanh Bin Mai, Yuebiao Zhou, Can Qin, Kai Ze Tee, Peng Liu*, Filippo Romiti*, Amir H. Hoveyda*

    Science 2024, 386, 167-175

    Science 2024, 386, 167-175

  • One-Pot Formal Carboradiofluorination of Alkenes: A Toolkit for
    Positron Emission Tomography Imaging Probe Development

    Mónica Rivas,# Sashi Debnath,# Sachin Giri, Yusuf M. Noffel, Xiankai Sun,* Vladimir Gevorgyan*

    J. Am. Chem. Soc. 2023, 145, 19265−19273

    J. Am. Chem. Soc. 2023, 145, 19265−19273

  • Streamlined Strategy for Scalable and Enantioselective Total
    Syntheses of the Eburnane Alkaloids

    Gujjula V. Ramakrishna,† Larisa P. Pop,† Zurwa Latif, Harish K. V. Suryadevara, Luca Santo, Filippo Romiti*

    J. Am. Chem. Soc. 2023, 145, 20062−20072

    J. Am. Chem. Soc. 2023, 145, 20062−20072

  • Asymmetric Intermolecular Allylic C–H Amination of Alkenes With Aliphatic Amines

    Kelvin Pak Shing Cheung, Jian Fang, Kallol Mukherjee, Andranik Mihranyan, Vladimir Gevorgyan*

    Science 2022, 378, 1207-1213

    Science 2022, 378,1207-1213